247 HEPATIC T1-TIME, CARDIAC STRUCTURE, FUNCTION AND CARDIOVASCULAR OTUCOMES IN PATIENTS WITH HEART FAILURE WITH REDUCED EJECTION FRACTION UNDERGOING CARDIAC MAGNETIC RESONANCE IMAGING

Abstract Aim Liver damage is frequently encountered in patients with cardiovascular (CV) disease, due to congestion or metabolic dysfunction-associated fatty liver disease (MAFLD). It has been shown that associated worse outcomes CV disease. Nevertheless, the association of cardiac structure and function events heart failure reduced ejection fraction (HFrEF) poorly known. Methods We retrospectively enrolled consecutive HFrEF undergoing Cardiac Magnetic Resonance (CMR) Imaging. In addition standard T1-mapping, 3 regions interest were also defined at parenchyma. Patients stratified according hepatic T1 mapping. Linear regression analysis adjusted for demographics clinical characteristics was performed cross-sectionally examine between T1-time on CMR measures function. The Kaplan-Meier survival Cox analyses prospectively investigate composite adverse outcome hospitalization HF all-cause death. Results Overall, 106 included study (mean age 56 ± 14 years, 75% male). Mean 558 70 ms. logistic analysis, left-ventricle (LV) end-diastolic volume (EDV) (p = 0.027), left atrial (LAV) 0.015), right-ventricle (RV) EDV < 0.001) RVEF 0.035) positively T1-time. Over a mean follow-up 5 2 32 (30%) experienced rate 6.7 per 100 person-year. higher independently an increased risk developing (adjusted-hazard ratio 1.07, 95% confidence interval: 1.01–1.12, p 0.011). particular, ≥558 ms had compared those <558 (log-rank 0.02). Conclusion Among CMR, significantly poorer size Hepatic rates all-cause-mortality. This parameter may be useful stratify outcomes.